Brian De Palma's Femme Fatale (2002) is an intricate eye-candy drama — one part film noir, one part Hitchcock, one part Mission Impossible. Connections to Mulholland Dr. include:
- Scenes filmed at the Cannes Film Festival in 2001 where David Lynch won Best Director for Mulholland Dr. Director Brian De Palma originally wanted to have Lynch in Femme Fatale arriving for the premiere of his film but with scheduling conflicts this didn't happen. In essence, this would mean that Mulholland Dr. would be the reason for Lynch's presence at Cannes making for a neat reference.
- The protagonist is also named Laure Watts — darn close to the first name/last name of the two protagonists in Mulholland Dr.: Laura Harring and Naomi Watts. Of note, Rebecca Romijn, like Naomi Watts (Betty/Diane), plays two characters: Laure/Lily.
- Another related plot point is the idea of the films both not being straight narratives. In Femme Fatale there is the issue of an attempted suicide attempt by a shot to the head and in MD we see a shot to the head. In MD we don't know that this occurs or whether it is a dream and in Femme Fatale it is also unclear. Overall, the ideas in both films involve the viewer determining what is reality and what is dream/alternate reality.
- Is Betty really Diane or are they merely dream-related look-a-likes? In Femme Fatale we have a woman take over the identity of a look-a-like.
- A more straightforward Mulholland Dr. reference is the girl/girl sex scene between a blonde and a brunette at Cannes.